دورية أكاديمية
Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles
| العنوان: | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
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| المؤلفون: | Ghazala Yaqub, Abdul Hannan, Erum Akbar, Muhammad Usman, Almas Hamid, Zubi Sadiq, Mehwish Iqbal |
| المصدر: | Journal of Chemistry, Vol 2013 (2013) |
| بيانات النشر: | Hindawi Limited, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA and S. typhi) and fungi (Candida albicans). Among tested compounds 3, 6, and 8 exhibited pronounced antibacterial activities while 2, 5, and 9 also showed moderate activities. 2, 3, 5, 7, and 9 showed stronger antifungal activity against Candida albicans comparable to positive control. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-9063 2090-9071 |
| Relation: | https://doaj.org/toc/2090-9063; https://doaj.org/toc/2090-9071 |
| DOI: | 10.1155/2013/818739 |
| URL الوصول: | https://doaj.org/article/81b8ea65952541f8a872b74b3d11380c |
| رقم الأكسشن: | edsdoj.81b8ea65952541f8a872b74b3d11380c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20909063 20909071 |
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| DOI: | 10.1155/2013/818739 |