دورية أكاديمية
Autologous transplantation of bone marrow mononuclear stem cells by mini-thoracotomy in dilated cardiomyopathy: technique and early results
العنوان: | Autologous transplantation of bone marrow mononuclear stem cells by mini-thoracotomy in dilated cardiomyopathy: technique and early results |
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المؤلفون: | Renato Abdala Karam Kalil, Daniele Ott, Roberto Sant'Anna, Eduardo Dias, João Pedro Marques-Pereira, Andrés Delgado-Cañedo, Nance Beyer Nardi, João Ricardo Michelin Sant'Anna, Paulo Roberto Prates, Ivo Nesralla |
المصدر: | São Paulo Medical Journal, Vol 126, Iss 2, Pp 75-81 |
بيانات النشر: | Associação Paulista de Medicina. |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | Dilated cardiomyopathy, Stem cells, Heart surgery, Heart failure, congestive, Cell transplantation, Medicine |
الوصف: | CONTEXT AND OBJECTIVES: There are few studies concerning bone marrow mononuclear cell (BMMC) transplantation in cases of nonischemic dilated cardiomyopathy. This study describes a novel technique of BMMC transplantation and the results up to one year after the procedure. DESIGN AND SETTING: This was a case series to evaluate the safety and viability of the procedure, at Instituto de Cardiologia do Rio Grande do Sul. METHODS: Nine patients with symptomatic dilated cardiomyopathy, functional class III/IV and left ventricular ejection fraction (LVEF) < 35% received BMMC (9.6 ± 2.6 x 107 cells) at 20 sites in the ventricular wall, by means of thoracotomy of length 5 cm in the fifth left intercostal space. Echocardiograms and nuclear magnetic resonance (NMR) were performed. RESULTS: There were no major complications. The functional class results for the first six patients (preoperatively and at two, four, eight and twelve-month follow-ups, respectively) were: [IV-2, III-4] to [I-5, II-1] to [I-3, II-3] to [I-2, II-3] and [I-2, II-3]. Echocardiograms showed LVEF: 25.9 ± 8.2; 32.9 ± 10.4; 29.4 ± 7.2; 25.1 ± 7.9; 25.4 ± 6.8% (p = 0.023); and % left ventricular (LV) fiber shortening: 12.6 ± 4.4; 16.4 ± 5.4; 14.3 ± 3.7; 12.1 ± 4.0; 12.2 ± 3.4% (p = 0.021). LV performance variation seen on NMR was non-significant. CONCLUSION: Intramyocardial transplantation of BMMC in dilated cardiomyopathy cases is feasible and safe. There were early improvements in symptoms and LV performance. Medium-term evaluation revealed regression of LV function, although maintaining improved functional class. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1806-9460 1516-3180 |
Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802008000200003&lng=en&tlng=en; https://doaj.org/toc/1806-9460 |
DOI: | 10.1590/S1516-31802008000200003 |
URL الوصول: | https://doaj.org/article/81cee7dcfa1841918e9c71afa7a13bf7 |
رقم الأكسشن: | edsdoj.81cee7dcfa1841918e9c71afa7a13bf7 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 18069460 15163180 |
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DOI: | 10.1590/S1516-31802008000200003 |