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Choriocapillaris Reperfusion in Resolved Chronic Central Serous Chorioretinopathy Treated with Eplerenone: Long-Term Effects on the Fellow Eye

التفاصيل البيبلوغرافية
العنوان: Choriocapillaris Reperfusion in Resolved Chronic Central Serous Chorioretinopathy Treated with Eplerenone: Long-Term Effects on the Fellow Eye
المؤلفون: Pasquale Viggiano, Giacomo Boscia, Enrico Borrelli, Lisa Toto, Maria Oliva Grassi, Federica Evangelista, Ermete Giancipoli, Giovanni Alessio, Francesco Boscia
المصدر: Ophthalmology and Therapy, Vol 12, Iss 6, Pp 3199-3210 (2023)
بيانات النشر: Adis, Springer Healthcare, 2023.
سنة النشر: 2023
المجموعة: LCC:Ophthalmology
مصطلحات موضوعية: Central serous chorioretinopathy, Choriocapillaris layer, Choroidal perfusion, Choroidal vascular changes, Optical coherence tomography angiography, Ophthalmology, RE1-994
الوصف: Abstract Introduction The aim of this work is to utilize swept-source optical coherence tomography angiography (SS-OCTA) to assess the long-term changes in the choroidal and choriocapillaris (CC) layers of the fellow unaffected eye of patients with unilateral resolved chronic central serous chorioretinopathy (cCSC) following treatment with continuous oral eplerenone (EPL). Methods The study included 35 patients with cCSC and subretinal fluid (SRF) in one eye. SS-OCTA imaging was performed on the fellow cCSC eyes at baseline, 6 months, and 12 months during eplerenone therapy. CC OCT angiography was analyzed to determine the percentage of choriocapillaris flow deficits (FD%), the number of flow deficits (FDn), and the average area of flow deficits (FDa). Results The results demonstrated significant changes in CC flow deficits from baseline to follow-up visits. Specifically, there was a significant decrease in FD% from 28.9 ± 2.2% at baseline to 26.4 ± 1.9% at 6 months (p = 0.023), and further to 24.9 ± 1.7% at 12 months (p = 0.001). Additionally, the FD area gradually contracted over the follow-up period (p 0.05). Conclusions The findings of this study demonstrated long-term reperfusion of the choriocapillaris in unaffected fellow cCSC eyes during continuous oral eplerenone therapy. The beneficial effects of eplerenone therapy were observed after 6 months and maintained at 1 year. These results suggest that specific mineralocorticoid receptor (MR) antagonists may be effective in promoting choriocapillaris recovery in the unaffected eyes of patients with cCSC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2193-8245
2193-6528
Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528
DOI: 10.1007/s40123-023-00816-8
URL الوصول: https://doaj.org/article/81d5972741474ce3a3bf83f9586ce26d
رقم الأكسشن: edsdoj.81d5972741474ce3a3bf83f9586ce26d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21938245
21936528
DOI:10.1007/s40123-023-00816-8