دورية أكاديمية
Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans
| العنوان: | Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans |
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| المؤلفون: | Lucia De la Cruz-Color, Jose Alfredo Dominguez-Rosales, Montserrat Maldonado-González, Bertha Ruíz-Madrigal, Martha P. Sánchez Muñoz, Vianney Alejandrina Zaragoza-Guerra, Victor H. Espinoza-Padilla, Elizabeth del C. Ruelas-Cinco, Sandra M. Ramírez-Meza, José R. Torres Baranda, María del R. González-Gutiérrez, Zamira Helena Hernandez Nazara |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 12, p 6420 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | leptin, leptin receptor, suppressor of cytokine signaling 3, sterol regulatory element-binding transcription factor 1, stearoyl-coa desaturase-1, patatin-like phospholipase domain-containing protein 2, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin resistance is not fully understood, and its contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This study evaluated the contribution of the leptin axis to MASLD in humans. Forty-three participants, mostly female (86.04%), who underwent cholecystectomy were biopsied. Of the participants, 24 were healthy controls, 8 had MASLD, and 11 had metabolic dysfunction-associated steatohepatitis (MASH). Clinical and biochemical data and the gene expression of leptin, leptin receptor (LEPR), suppressor of cytokine signaling 3 (SOCS3), sterol regulatory element-binding transcription factor 1 (SREBF1), stearoyl-CoA desaturase-1 (SCD1), and patatin-like phospholipase domain-containing protein 2 (PNPLA2), were determined from liver and adipose tissue. Higher serum leptin and LEPR levels in the omental adipose tissue (OAT) and liver with MASH were found. In the liver, LEPR was positively correlated with leptin expression in adipose tissue, and SOCS3 was correlated with SREBF1-SCD1. In OAT, SOCS3 was correlated with insulin resistance and transaminase enzymes (p < 0.05 for all. In conclusion, we evidenced the correlation between the peripheral leptin resistance axis in OAT–liver crosstalk and the complications of MASLD in humans. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/12/6420; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25126420 |
| URL الوصول: | https://doaj.org/article/81d6b55c878146b9a7fb38e5cece356b |
| رقم الأكسشن: | edsdoj.81d6b55c878146b9a7fb38e5cece356b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25126420 |