دورية أكاديمية
Prenatal exposure to ambient air pollution is associated with neurodevelopmental outcomes at 2 years of age
| العنوان: | Prenatal exposure to ambient air pollution is associated with neurodevelopmental outcomes at 2 years of age |
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| المؤلفون: | Zachariah E. M. Morgan, Maximilian J. Bailey, Diana I. Trifonova, Noopur C. Naik, William B. Patterson, Frederick W. Lurmann, Howard H. Chang, Bradley S. Peterson, Michael I. Goran, Tanya L. Alderete |
| المصدر: | Environmental Health, Vol 22, Iss 1, Pp 1-13 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Industrial medicine. Industrial hygiene LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Neurodevelopment, Air Pollution, Health Disparities, Child Development, Pregnancy Exposures, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Background Higher prenatal ambient air pollution exposure has been associated with impaired neurodevelopment in preschoolers and school-aged children. The purpose of this study was to explore the relationships between prenatal ambient air pollution exposure and neurodevelopment during infancy. Methods This study examined 161 Latino mother-infant pairs from the Southern California Mother’s Milk Study. Exposure assessments included prenatal nitrogen dioxide (NO2) and particulate matter smaller than 2.5 and 10 microns in diameter (PM2.5 and PM10, respectively). The pregnancy period was also examined as three windows, early, mid, and late, which describe the first, middle, and last three months of pregnancy. Infant neurodevelopmental outcomes at 2 years of age were measured using the Bayley-III Scales of Infant and Toddler Development. Multivariable linear models and distributed lag linear models (DLM) were used to examine relationships between prenatal exposures and neurodevelopmental scores, adjusting for socioeconomic status, breastfeeding frequency, time of delivery, pre-pregnancy body mass index, and infant birthweight and sex. Results Higher prenatal exposure to PM10 and PM2.5 was negatively associated with composite cognitive score (β = -2.01 [-3.89, -0.13] and β = -1.97 [-3.83, -0.10], respectively). In addition, higher average prenatal exposure to PM10 was negatively associated with composite motor (β = -2.35 [-3.95, -0.74]), scaled motor (β = -0.77 [-1.30, -0.24]), gross motor (β = -0.37 [-0.70, -0.04]), fine motor (β = -0.40 [-0.71, -0.09]), composite language (β = -1.87 [-3.52, -0.22]), scaled language (β = -0.61 [-1.18, -0.05]) and expressive communication scaled scores (β = -0.36 [-0.66, -0.05]). DLMs showed that higher prenatal air pollution exposure during mid and late pregnancy was inversely associated with motor, cognitive, and communication language scores. Conclusions Higher exposure to air pollutants during pregnancy, particularly in the mid and late prenatal periods, was inversely associated with scaled and composite motor, cognitive, and language scores at 2 years. These results indicate that prenatal ambient air pollution may negatively impact neurodevelopment in early life. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-069X |
| Relation: | https://doaj.org/toc/1476-069X |
| DOI: | 10.1186/s12940-022-00951-y |
| URL الوصول: | https://doaj.org/article/81fb25ac9c8345a38d0f31838e9c4bc2 |
| رقم الأكسشن: | edsdoj.81fb25ac9c8345a38d0f31838e9c4bc2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476069X |
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| DOI: | 10.1186/s12940-022-00951-y |