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Neutrophil-Initiated Myocardial Inflammation and Its Modulation by B-Type Natriuretic Peptide: A Potential Therapeutic Target

التفاصيل البيبلوغرافية
العنوان: Neutrophil-Initiated Myocardial Inflammation and Its Modulation by B-Type Natriuretic Peptide: A Potential Therapeutic Target
المؤلفون: Saifei Liu, Yuliy Y. Chirkov, John D. Horowitz
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 1, p 129 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: “neutrophil burst”, BNP, heart failure, takotsubo syndrome, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Activation of neutrophils is a critically important component of the innate immune response to bacterial and chemical stimuli, and culminates in the “neutrophil burst”, which facilitates neutrophil phagocytosis via the release of superoxide anion radical (O2−) from NADPH oxidase. Excessive and/or prolonged neutrophil activation results in substantial tissue injury and increases in vascular permeability—resulting in sustained tissue infiltration with neutrophils and monocytes, and persistent vasomotor dysfunction. Cardiovascular examples of such changes include acute and chronic systolic and diastolic heart failure (“heart failure with preserved ejection fraction”), and the catecholamine-induced inflammatory disorder takotsubo syndrome. We have recently demonstrated that B-type natriuretic peptide (BNP), acting via inhibition of activation of neutrophil NADPH oxidase, is an important negative modulator of the “neutrophil burst”, though its effectiveness in limiting tissue injury is partially lost in acute heart failure. The potential therapeutic implications of these findings, regarding the development of new means of treating both acute and chronic cardiac injury states, are discussed.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: http://www.mdpi.com/1422-0067/20/1/129; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms20010129
URL الوصول: https://doaj.org/article/81fb9dcdd74f4d2097fe9d1e75e2dd15
رقم الأكسشن: edsdoj.81fb9dcdd74f4d2097fe9d1e75e2dd15
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms20010129