دورية أكاديمية
Recent advances in development of nano-carriers for immunogene therapy in various complex disorders
| العنوان: | Recent advances in development of nano-carriers for immunogene therapy in various complex disorders |
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| المؤلفون: | Sanaz Shahgordi, Fatemeh Oroojalian, Ezzat Hashemi, Maryam Hashemi |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 25, Iss 2, Pp 134-147 (2022) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | gene delivery, immunogene therapy, immunotherapy, nano-carriers, Medicine |
| الوصف: | Immunotherapy is a novel preference for the treatment of various complex diseases. Considering the application of varying agents for suppression or activation of the immune system, immunogene therapy was confirmed to stand as a proper alternative for other immunotherapeutic strategies due to its capability in targeting cells with more specificity that leads to controlling the expression of therapeutic genes. This method facilitates the local and single-dose application of most gene therapies that result in the usage of high therapeutic doses with a low risk of systemic side effects while being cost-efficient in long-term administrations. However, the existing barriers between the administration site and cell nucleus limited the clinical uses of genetic materials. These challenges can be overcome through the promising method of exerting non-carriers with high stability, low toxicity/immunogenicity, and simple modifications. In this study, we attempted to review the potential of nanoparticle application throughout the immunogene therapy of different diseases including cancer, microbial diseases, allergies, inflammatory bowel disease, rheumatoid arthritis, and respiratory infections. We included the outline of some challenges and opportunities in regards to the delivery of genetic materials that are based on nano-systems through immunotherapy of these disorders. Next to the promising future of these vectors, more detailed analyses are required to overcome the current limitations in clinical approaches. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | https://ijbms.mums.ac.ir/article_19631_99da24f84704970cf71d4b13582bc0f0.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2022.59718.13245 |
| URL الوصول: | https://doaj.org/article/c823d77f0961407ba5e3cf1ee350a902 |
| رقم الأكسشن: | edsdoj.823d77f0961407ba5e3cf1ee350a902 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2022.59718.13245 |