دورية أكاديمية
Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration
العنوان: | Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration |
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المؤلفون: | Huachun Wang, Ruixue Sun, Shengyun Huang, Haiwei Wu, Dongsheng Zhang |
المصدر: | Heliyon, Vol 10, Iss 5, Pp e25832- (2024) |
بيانات النشر: | Elsevier, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
مصطلحات موضوعية: | Chitosan, Hydroxyapatite, Periostin, Composite scaffold, Bone regeneration, Science (General), Q1-390, Social sciences (General), H1-99 |
الوصف: | This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaffold. When applied to the repair of bone defect in a rat mandibular model, the HAp/CS scaffold loaded with periostin can enhance osteointegration and accelerate bone regeneration. Our research combines periostin with the HAp/CS composite material, which provides a novel strategy to improve bone regeneration and has great application prospect in bone repair fields. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2405-8440 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024018632; https://doaj.org/toc/2405-8440 |
DOI: | 10.1016/j.heliyon.2024.e25832 |
URL الوصول: | https://doaj.org/article/825295d4beb444cdaf3469fbb6144694 |
رقم الأكسشن: | edsdoj.825295d4beb444cdaf3469fbb6144694 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 24058440 |
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DOI: | 10.1016/j.heliyon.2024.e25832 |