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Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration

التفاصيل البيبلوغرافية
العنوان: Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration
المؤلفون: Huachun Wang, Ruixue Sun, Shengyun Huang, Haiwei Wu, Dongsheng Zhang
المصدر: Heliyon, Vol 10, Iss 5, Pp e25832- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Chitosan, Hydroxyapatite, Periostin, Composite scaffold, Bone regeneration, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaffold. When applied to the repair of bone defect in a rat mandibular model, the HAp/CS scaffold loaded with periostin can enhance osteointegration and accelerate bone regeneration. Our research combines periostin with the HAp/CS composite material, which provides a novel strategy to improve bone regeneration and has great application prospect in bone repair fields.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024018632; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e25832
URL الوصول: https://doaj.org/article/825295d4beb444cdaf3469fbb6144694
رقم الأكسشن: edsdoj.825295d4beb444cdaf3469fbb6144694
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e25832