دورية أكاديمية
Identification of novel biomarkers for lupus nephritis
| العنوان: | Identification of novel biomarkers for lupus nephritis |
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| المؤلفون: | Zhengyue Liao, Liying He, Jiaojiao Fu, Xiaotong Zhou, Yong Li, Jing He, Yixin Liu, Jinlin Guo, Sijing Liu |
| المصدر: | Biomolecules & Biomedicine (2024) |
| بيانات النشر: | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Immune cells, lupus nephritis, differentially expressed genes, Biology (General), QH301-705.5 |
| الوصف: | Lupus nephritis (LN) is an autoimmune disease that rapidly progresses as a secondary consequence of systemic lupus erythematosus (SLE) and has a very poor prognosis. Therefore, this study aimed to identify characteristics of immune cell infiltration and investigate potential therapeutic targets using bioinformatics methods and the Murphy Roths Large/lymphoproliferation (MRL/lpr) mouse model. In this study, a total of 2,810 differentially expressed genes (DEGs) were identified, which were primarily enriched in inflammatory and immune regulation pathways. From these DEGs, 226 immune-related genes (IRGs) were also identified. The single-sample gene set enrichment analysis (ssGSEA) revealed that patients with LN had increased infiltration of effector memory CD4+ T cells, effector memory CD8+ T cells, gamma delta T cells, myeloid-derived suppressor cells (MDSC), follicular helper T cells, Th1 cells, and Th2 cells, and this was closely correlated with the DEG-IRGs. Furthermore, the potential therapeutic biomarkers, CD244, S100 calcium binding protein P (S100P), and vascular endothelial growth factor C (VEGFC), were identified by Random Forest Approach (RFA), which were validated in LN mice. These findings provide new evidence and insights for further research on diagnosis and treatment of LN by identifying critical genes and their associations with immune infiltration. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2831-0896 2831-090X |
| Relation: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10450; https://doaj.org/toc/2831-0896; https://doaj.org/toc/2831-090X |
| DOI: | 10.17305/bb.2024.10450 |
| URL الوصول: | https://doaj.org/article/82835accbcac49f89d4f36fde8e0ed66 |
| رقم الأكسشن: | edsdoj.82835accbcac49f89d4f36fde8e0ed66 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 28310896 2831090X |
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| DOI: | 10.17305/bb.2024.10450 |