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Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

التفاصيل البيبلوغرافية
العنوان: Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats
المؤلفون: P.C. Agu, P.M. Aja, Ezebuilo Ekpono Ugbala, H.A. Ogwoni, E.M. Ezeh, P.C. Oscar-Amobi, Agbor Asuk Atamgba, O.G. Ani, J.N. Awoke, F.E. Nwite, O.U. Ukachi, O.U. Orji, P.C. Nweke, Ejike Ekpono Ugbala, G.O. Ewa, I.O. Igwenyi, C.O. Egwu, E.U. Alum, D.C. Chukwu, A.C. Famurewa
المصدر: Heliyon, Vol 8, Iss 3, Pp e09162- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Bisphenol A, Cucumeropsis mannii, Testicular toxicity, Nutraceuticals, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Background: Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. Methods: A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. Results: BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. Conclusions: CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844022004509; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2022.e09162
URL الوصول: https://doaj.org/article/82ac1f24d8514328adf81fbb486b8c9b
رقم الأكسشن: edsdoj.82ac1f24d8514328adf81fbb486b8c9b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2022.e09162