دورية أكاديمية
Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats
العنوان: | Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats |
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المؤلفون: | P.C. Agu, P.M. Aja, Ezebuilo Ekpono Ugbala, H.A. Ogwoni, E.M. Ezeh, P.C. Oscar-Amobi, Agbor Asuk Atamgba, O.G. Ani, J.N. Awoke, F.E. Nwite, O.U. Ukachi, O.U. Orji, P.C. Nweke, Ejike Ekpono Ugbala, G.O. Ewa, I.O. Igwenyi, C.O. Egwu, E.U. Alum, D.C. Chukwu, A.C. Famurewa |
المصدر: | Heliyon, Vol 8, Iss 3, Pp e09162- (2022) |
بيانات النشر: | Elsevier, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
مصطلحات موضوعية: | Bisphenol A, Cucumeropsis mannii, Testicular toxicity, Nutraceuticals, Science (General), Q1-390, Social sciences (General), H1-99 |
الوصف: | Background: Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. Methods: A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. Results: BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. Conclusions: CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2405-8440 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2405844022004509; https://doaj.org/toc/2405-8440 |
DOI: | 10.1016/j.heliyon.2022.e09162 |
URL الوصول: | https://doaj.org/article/82ac1f24d8514328adf81fbb486b8c9b |
رقم الأكسشن: | edsdoj.82ac1f24d8514328adf81fbb486b8c9b |
قاعدة البيانات: | Directory of Open Access Journals |
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