A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells

التفاصيل البيبلوغرافية
العنوان:	A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells
المؤلفون:	Timothy K. Turkalo, Antonio Maffia, Johannes J. Schabort, Samuel G. Regalado, Mital Bhakta, Marco Blanchette, Diana C. J. Spierings, Peter M. Lansdorp, Dirk Hockemeyer
المصدر:	Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
بيانات النشر:	Nature Portfolio, 2023.
سنة النشر:	2023
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Mutations of ATRX are frequent in cancers that immortalize through the ALT (Alternative lengthening of telomeres) pathway. Here the authors show that ALT features are repressed in embryonic stem cells that lack ATRX but induced by continuous telomere instability triggered upon cell differentiation.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-023-36294-6
URL الوصول:	https://doaj.org/article/c82b5c4319a248149ad833c8327f0f16
رقم الأكسشن:	edsdoj.82b5c4319a248149ad833c8327f0f16
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-023-36294-6