دورية أكاديمية
XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair
| العنوان: | XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair |
|---|---|
| المؤلفون: | Weimin Dai, An Wu, Yunping Li, Guofeng Yu, Xinjiang Yan |
| المصدر: | Cell Transplantation, Vol 31 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentosum group A (XPA), a pivotal DNA damage recognition protein implicated in nucleotide excision repair (NER), we devised a novel method to enhance glioblastoma therapy and alleviate temozolomide resistance. On the basis of preliminary assessment, we found that XPA dramatically increased in glioblastoma compared with normal cells and contributed to temozolomide resistance. By constructing XPA stably knockdown cells, we illustrate that XPA protects glioma cells from temozolomide-triggered reproductive cell death, apoptosis, as well as DNA repair. Besides, XPA silencing remarkably enhances temozolomide efficacy in vivo . This study revealed a crucial function of XPA-dependent NER in the resistance of glioma cells to temozolomide. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1555-3892 09636897 |
| Relation: | https://doaj.org/toc/1555-3892 |
| DOI: | 10.1177/09636897221092778 |
| URL الوصول: | https://doaj.org/article/82c7448ba4de4741afa189f5a7957e4d |
| رقم الأكسشن: | edsdoj.82c7448ba4de4741afa189f5a7957e4d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15553892 09636897 |
|---|---|
| DOI: | 10.1177/09636897221092778 |