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Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats

التفاصيل البيبلوغرافية
العنوان: Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats
المؤلفون: J. Matiasovic, L. Leva, J. Maskova, V. Kummer, M. Faldyna
المصدر: Veterinární Medicína, Vol 53, Iss 2, Pp 93-100 (2008)
بيانات النشر: Czech Academy of Agricultural Sciences, 2008.
سنة النشر: 2008
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: polycyclic aromatic hydrocarbons, immunity, ifn-γ, / il-4, cytokines, Veterinary medicine, SF600-1100
الوصف: To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-γ and IL-4 (measured at the mRNA level) as well as the decreasing IFN-γ /IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0375-8427
1805-9392
Relation: https://vetmed.agriculturejournals.cz/artkey/vet-200802-0005_effects-of-postnatal-exposure-to-benzo-a-pyrene-on-the-immunity-of-immature-rats.php; https://doaj.org/toc/0375-8427; https://doaj.org/toc/1805-9392
DOI: 10.17221/1986-VETMED
URL الوصول: https://doaj.org/article/832ed0411c55473eb4b9291fbfdc6438
رقم الأكسشن: edsdoj.832ed0411c55473eb4b9291fbfdc6438
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03758427
18059392
DOI:10.17221/1986-VETMED