دورية أكاديمية
Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Polydeoxyribonucleotide in the Treatment of Knee Osteoarthritis
| العنوان: | Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Polydeoxyribonucleotide in the Treatment of Knee Osteoarthritis |
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| المؤلفون: | Seihee Yoon, Jung Joong Kang, Jungin Kim, Seunghun Park, Jong Moon Kim |
| المصدر: | Annals of Rehabilitation Medicine, Vol 43, Iss 2, Pp 204-214 (2019) |
| بيانات النشر: | Korean Academy of Rehabilitation Medicine, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Knee osteoarthritis, Intra-articular injections, Hyaluronic acid, Polydeoxyribonucleotides, Medicine |
| الوصف: | Objective To assess the clinical efficacy and safety of intra-articular injection of hyaluronic acid (HA) combined with polydeoxyribonucleotide (PDRN) in patients with knee osteoarthritis in comparison with that of HA alone. Methods The current single-center, prospective, randomized, double-blind, controlled study was conducted in 36 patients with knee osteoarthritis at our medical institution. All the eligible patients (n=30) were equally assigned to two treatment arms (trial group ‘HA+PDRN’ and control group ‘HA’). For efficacy assessment, the patients were evaluated for the visual analogue scale (VAS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee Society Scores (KSS), all of which served as efficacy outcome measures. We monitored time-dependent changes in efficacy outcome measures at baseline and 1, 3 and 6 months. Subsequently, we compared differences in changes in efficacy outcome measures at 6 months from baseline between the two groups. Moreover, we assessed the safety based on the treatment-emergent adverse events (TEAEs), adverse drug reactions (ADRs) and any other complications serving as safety outcome measures. Results There were significant differences in changes in the VAS scores, the WOMAC scores in all domains, except ‘Stiffness’, the total WOMAC scores, and the KSS scores in all the domains at 6 months from baseline between the two groups (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2234-0645 2234-0653 |
| Relation: | http://www.e-arm.org/upload/pdf/arm-2019-43-2-204.pdf; https://doaj.org/toc/2234-0645; https://doaj.org/toc/2234-0653 |
| DOI: | 10.5535/arm.2019.43.2.204 |
| URL الوصول: | https://doaj.org/article/c835617925814104a33eb696cb23ed1e |
| رقم الأكسشن: | edsdoj.835617925814104a33eb696cb23ed1e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22340645 22340653 |
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| DOI: | 10.5535/arm.2019.43.2.204 |