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Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells

التفاصيل البيبلوغرافية
العنوان: Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells
المؤلفون: Chaves NL, Estrela-Lopis I, Böttner J, Lopes CAP, Guido BC, de Souza AR, Báo SN
المصدر: International Journal of Nanomedicine, Vol Volume 12, Pp 5511-5523 (2017)
بيانات النشر: Dove Medical Press, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: Maghemite, nanomaterials, cells uptake, endocytosis., Medicine (General), R5-920
الوصف: Natalia L Chaves,1 Irina Estrela-Lopis,2 Julia Böttner,2 Cláudio AP Lopes,1 Bruna C Guido,1 Aparecido R de Sousa,3 Sônia N Báo1 1Institute of Biological Sciences, Department of Cell Biology, University of Brasília (UnB), Brasília, Brazil; 2Institute of Biophysics and Medical Physics, University of Leipzig, Leipzig, Germany; 3Institute of Chemistry, Federal University of Goiás, Goiânia, Brazil Abstract: Nanocarriers have the potential to improve the therapeutic index of currently available drugs by improving their efficacy and achieving therapeutic steady-state levels over an extended period. The association of maghemite–rhodium citrate (MRC) nanoparticles (NPs) has the potential to increase specificity of the cytotoxic action. However, the interaction of these NPs with cells, their uptake mechanism, and subcellular localization need to be elucidated. This work evaluates the uptake mechanism of MRC NPs in metastatic and nonmetastatic breast cancer-cell models, comparing them to a nontumor cell line. MRC NPs uptake in breast cancer cells was more effective than in normal cells, with regard to both the amount of internalized material and the achievement of more strategic intracellular distribution. Moreover, this process occurred through a clathrin-dependent endocytosis pathway with different basal expression levels of this protein in the cell lines tested. Keywords: maghemite, nanomaterials, cells uptake, endocytosis
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-2013
88729257
Relation: https://www.dovepress.com/exploring-cellular-uptake-of-iron-oxide-nanoparticles-associated-with--peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013
URL الوصول: https://doaj.org/article/8379ee08656c43b887292574eb22e4c1
رقم الأكسشن: edsdoj.8379ee08656c43b887292574eb22e4c1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11782013
88729257