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Improved patient-reported outcomes in patients with psoriatic arthritis treated with risankizumab: analysis of the Phase 3 trial KEEPsAKE 2

التفاصيل البيبلوغرافية
العنوان: Improved patient-reported outcomes in patients with psoriatic arthritis treated with risankizumab: analysis of the Phase 3 trial KEEPsAKE 2
المؤلفون: Kurt de Vlam, Alan Kivitz, Andrew J K Ostor, Zailong Wang, Ahmed M Soliman, Ann Eldred, Kim A Papp, Byron Padilla
المصدر: RMD Open, Vol 8, Iss 2 (2022)
بيانات النشر: BMJ Publishing Group, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: Objectives Determine the impact of 24-week risankizumab (RZB) versus placebo (PBO) on patient-reported outcomes (PROs) in patients with psoriatic arthritis (PsA) and inadequate response to one or two biologics (Bio-IR) and/or ≥1 conventional synthetic disease-modifying antirheumatic drug (csDMARD-IR).Methods Patients in the Phase 3 trial, KEEPsAKE 2, were randomised (1:1) to RZB 150 mg or PBO by subcutaneous injection. PROs assessed: 36-Item Short-Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-Fatigue), Patient’s Assessment of Pain by visual analogue scale (VAS), Patient’s global assessment of disease activity (PtGA), EuroQoL-5 Dimension-5 Level (EQ-5D-5L) and Work Productivity and Activity Impairment—PsA (WPAI-PsA). Least squares mean change from baseline at week 24 was compared between RZB versus PBO by mixed-effects repeated regression modelling.Results At week 24, RZB versus PBO treatment resulted in significant differences (95% CIs) in mean change from baseline in ranked secondary endpoints SF-36 physical component summary score (3.9 (2.4 to 5.3); p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2022-0022
2056-5933
Relation: https://rmdopen.bmj.com/content/8/2/e002286.full; https://doaj.org/toc/2056-5933
DOI: 10.1136/rmdopen-2022-002286
URL الوصول: https://doaj.org/article/838882eaf5b84a6c88601c84524195e0
رقم الأكسشن: edsdoj.838882eaf5b84a6c88601c84524195e0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20220022
20565933
DOI:10.1136/rmdopen-2022-002286