دورية أكاديمية
أعرض في EDS

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells.

التفاصيل البيبلوغرافية
العنوان: Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells.
المؤلفون: André Uitterdijk, Bianca C W Groenendijk, Charlotte Gorsse-Bakker, Anna Panasewicz, Stefan Sneep, Dennie Tempel, Esther H van de Kamp, Daphne Merkus, Willem J van der Giessen, Dirk J Duncker
المصدر: PLoS ONE, Vol 12, Iss 6, p e0178779 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Intracoronary infusion of autologous bone marrow-derived mononuclear cells (BMMNC), after acute myocardial infarction (AMI), has been shown to improve myocardial function. However, therapeutic efficacy is limited, possibly because cell retention rates are low, suggesting that optimization of cell retention might increase therapeutic efficacy. Since retention of injected BMMNC is observed only within infarcted, but not remote, myocardium, we hypothesized that adhesion molecules on activated endothelium following reperfusion are essential. Consequently, we investigated the role of vascular cell adhesion molecule 1 (VCAM-1) in BMMNC retention in swine undergoing reperfused AMI produced by 120 min of percutaneous left circumflex coronary occlusion.VCAM-1 expression in the infarct and remote region was quantified at 1, 3, 7, 14, and 35 days, post-reperfusion (n≥6 swine per group). Since expression levels were significantly higher at 3 days (2.41±0.62%) than at 7 days (0.98±0.28%; p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5476248?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0178779
URL الوصول: https://doaj.org/article/a83bba91e2974dffba77af5086c3d7df
رقم الأكسشن: edsdoj.83bba91e2974dffba77af5086c3d7df
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0178779