دورية أكاديمية
Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform
| العنوان: | Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform |
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| المؤلفون: | Heng Zhou, Ziwei Li, Shuili Jing, Ben Wang, Zhifei Ye, Wei Xiong, Yonghao Liu, Ye Liu, Chun Xu, Tushar Kumeria, Yan He, Qingsong Ye |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-24 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | SeNPs, SeNPs@ZIF-8, Spinal cord injury, Reactive oxygen species, Neural regeneration, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of the cascade reaction, the effect of excessive reactive oxygen species (ROS) in the early and middle stages of SCI severely damage neurons, and most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads to a huge compromise in antioxidant treatment of SCI. Selenium nanoparticles (SeNPs) have excellent ROS scavenging bioactivity, but the toxicity control problem limits the therapeutic window. Here, we propose a synergistic therapeutic strategy of SeNPs encapsulated by ZIF-8 (SeNPs@ZIF-8) to obtain synergistic ROS scavenging activity. Three different spatial structures of SeNPs@ZIF-8 were synthesized and coated with ferrostatin-1, a ferroptosis inhibitor (FSZ NPs), to achieve enhanced anti-oxidant and anti-ferroptosis activity without toxicity. FSZ NPs promoted the maintenance of mitochondrial homeostasis, thereby regulating the expression of inflammatory factors and promoting the polarization of macrophages into M2 phenotype. In addition, the FSZ NPs presented strong abilities to promote neuronal maturation and axon growth through activating the WNT4-dependent pathways, while prevented glial scar formation. The current study demonstrates the powerful and versatile bioactive functions of FSZ NPs for SCI treatment and offers inspiration for other neural injury diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-024-02610-5 |
| URL الوصول: | https://doaj.org/article/83e0e126bc4a423da6a989ac103f942b |
| رقم الأكسشن: | edsdoj.83e0e126bc4a423da6a989ac103f942b |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-024-02610-5 |