دورية أكاديمية
Microneedling with a Novel, n-3-PUFA-Rich Formulation Accelerates Inflammation Resolution to Improve Skin Recovery Outcomes in Adults with Healthy Skin
| العنوان: | Microneedling with a Novel, n-3-PUFA-Rich Formulation Accelerates Inflammation Resolution to Improve Skin Recovery Outcomes in Adults with Healthy Skin |
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| المؤلفون: | Russell Wong, Angela Murphy, Monica Lira, Mariangela G. de O. Sichmann, Alexis R. Kim, Veronica D. Saechee, Kevin D. Hermanson, Stacy S. Hawkins |
| المصدر: | Dermatology and Therapy, Vol 13, Iss 12, Pp 3057-3069 (2023) |
| بيانات النشر: | Adis, Springer Healthcare, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | Inflammation resolution, Micro-injury, Microneedling, Omega-3, Skin care, Skin rejuvenation, Dermatology, RL1-803 |
| الوصف: | Abstract Introduction Microneedling is a cosmetic procedure that leverages the skin’s natural ability to heal in order to promote collagen formation and skin rejuvenation. To provide improved results, the technique can be combined with topical formulations. A new formulation of multiple actives, including omega-3 (n-3) polyunsaturated fatty acids (PUFAs), was designed to accelerate the resolution of inflammation and wound healing following micro-injury treatments, while enhancing the visible appearance of procedure results, including erythema, luminosity and skin texture. Methods In this randomised, controlled, split-face study, we examined 32 healthy female participants aged 30–70 years for 4 weeks following microneedling treatment with a novel multiple-active-ingredient formulation or conventional microneedling protocol with a hyaluronic acid control serum. Changes in skin condition were assessed by blinded clinical photography and expert evaluation. Measurements were collected at baseline, 1 h, 1 day, 7 days and 28 days post treatment. Results Significantly greater improvements in expert-assessed erythema, luminosity and skin texture were reported following application of the novel multiple-active-ingredient formulation than the hyaluronic acid control serum. This was confirmed by representative VISIA®-CR imaging. Conclusion These data provide new evidence for the role of a novel multiple-active-ingredient formulation for improving skin outcomes up to 28 days following microneedling in adults with healthy skin when compared with a hyaluronic acid serum. The n-3 PUFA content of this formulation may drive accelerated inflammation resolution and wound healing alongside the complementary action of the other active ingredients, leading to the observed improvements in erythema, luminosity and skin texture. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8210 2190-9172 |
| Relation: | https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172 |
| DOI: | 10.1007/s13555-023-01049-0 |
| URL الوصول: | https://doaj.org/article/83e802d1f37d477fb056efb2db3af681 |
| رقم الأكسشن: | edsdoj.83e802d1f37d477fb056efb2db3af681 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21938210 21909172 |
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| DOI: | 10.1007/s13555-023-01049-0 |