دورية أكاديمية
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
| العنوان: | Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria |
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| المؤلفون: | Holmberg Ville, Onkamo Päivi, Lahtela Elisa, Lahermo Päivi, Bedu-Addo George, Mockenhaupt Frank P, Meri Seppo |
| المصدر: | Malaria Journal, Vol 11, Iss 1, p 61 (2012) |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Lectin pathway, Mannose-binding lectin, MBL2, MASP2, Ficolin, Complement, Innate immunity, Malaria, Placenta, Pregnancy, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood. Methods 98 single-nucletoide polymorphisms were genotyped in a set of 17 functionally related genes of the complement system in 145 primiparous Ghanaian women with placental malaria, defined by placental parasitaemia or malaria pigment, and as a control, in 124 non-affected primiparae. Results Placental malaria was significantly associated with SNPs in the lectin pathway genes MBL2, MASP2, FCN2 and in properdin. In particular, the main African mannose-binding lectin deficiency variant (MBL2*G57E, rs1800451) increased the odds of placental malaria (OR 1.6; permuted p-value 0.014). In contrast, a common MASP2 mutation (R439H, rs12085877), which reduces the activity of MBL-MASP2 complexes occurred in 33% of non-affected women and in 22% primiparae with placental malaria (OR 0.55, permuted p-value 0.020). Conclusions Excessive complement activation is of importance in the pathogenesis of placental malaria by mediating inflammation, coagulation, and endothelial dysfunction. Mutated MBL and MASP2 proteins could have direct intrinsic effects on the susceptibility to placental malaria, in addition to their roles in regulation of downstream complement activation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2875 |
| Relation: | http://www.malariajournal.com/content/11/1/61; https://doaj.org/toc/1475-2875 |
| DOI: | 10.1186/1475-2875-11-61 |
| URL الوصول: | https://doaj.org/article/8415ae8a90c745dca5a327d6310103ee |
| رقم الأكسشن: | edsdoj.8415ae8a90c745dca5a327d6310103ee |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752875 |
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| DOI: | 10.1186/1475-2875-11-61 |