دورية أكاديمية
Disruption of interferon-β production by the Npro of atypical porcine pestivirus
| العنوان: | Disruption of interferon-β production by the Npro of atypical porcine pestivirus |
|---|---|
| المؤلفون: | Chunxiao Mou, Shuonan Pan, Huiguang Wu, Zhenhai Chen |
| المصدر: | Virulence, Vol 12, Iss 1, Pp 654-665 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | atypical porcine pestivirus, nonstructural protein npro, ifn-β production, ifn regulatory factor 3, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Atypical porcine pestivirus (APPV) is an emerging porcine virus that threatens global swine production. Pestiviruses can prevent interferon (IFN) production to avoid the host innate immune response, and the Npro viral protein can play a critical role. Knowledge of the host immune response to APPV infection is limited. Here, we showed that the IFN-β production was suppressed by APPV-Npro and the IFN regulatory factor 3 (IRF3) promoter activity stimulated by adaptor molecules of the IFN-β signaling pathway was also inhibited in the APPV-Npro-expressed cells. The APPV-Npro was able to interact with IRF3 and interfere the phosphorylation of IRF3, indicated that the IFN-β antagonism of APPV-Npro mainly depended on blocking IRF3 activity. To identify the functional region of APPV-Npro, a panel of truncated APPV-Npro was constructed, and its influence on the IRF3 activation was investigated. The results showed that the N-terminal 31–51 amino acids of APPV-Npro were mainly associated with inhibition of the IFN-β response. Taken together, this is the first study focusing on elucidating the function of APPV protein by revealing a novel mechanism of Npro in disruption of host IFN-β production, which will enlighten future study in addressing APPV pathogenesis and immune evasion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| Relation: | https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608 |
| DOI: | 10.1080/21505594.2021.1880773 |
| URL الوصول: | https://doaj.org/article/84665363b4634900bb972066a3e1349f |
| رقم الأكسشن: | edsdoj.84665363b4634900bb972066a3e1349f |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher 
Full Text Finder | تدمد: | 21505594 21505608 |
|---|---|
| DOI: | 10.1080/21505594.2021.1880773 |