دورية أكاديمية
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
| العنوان: | Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses |
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| المؤلفون: | Jiarui Li, Ester Boix |
| المصدر: | Virulence, Vol 12, Iss 1, Pp 444-469 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | enveloped single-stranded rna viruses, virus-host interplay, rnases, innate immunity, antiviral drugs, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Owing to the recent outbreak of Coronavirus Disease of 2019 (COVID-19), it is urgent to develop effective and safe drugs to treat the present pandemic and prevent other viral infections that might come in the future. Proteins from our own innate immune system can serve as ideal sources of novel drug candidates thanks to their safety and immune regulation versatility. Some host defense RNases equipped with antiviral activity have been reported over time. Here, we try to summarize the currently available information on human RNases that can target viral pathogens, with special focus on enveloped single-stranded RNA (ssRNA) viruses. Overall, host RNases can fight viruses by a combined multifaceted strategy, including the enzymatic target of the viral genome, recognition of virus unique patterns, immune modulation, control of stress granule formation, and induction of autophagy/apoptosis pathways. The review also includes a detailed description of representative enveloped ssRNA viruses and their strategies to interact with the host and evade immune recognition. For comparative purposes, we also provide an exhaustive revision of the currently approved or experimental antiviral drugs. Finally, we sum up the current perspectives of drug development to achieve successful eradication of viral infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| Relation: | https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608 |
| DOI: | 10.1080/21505594.2021.1871823 |
| URL الوصول: | https://doaj.org/article/c847fb9b56aa45a7a3dc7d6b62be317c |
| رقم الأكسشن: | edsdoj.847fb9b56aa45a7a3dc7d6b62be317c |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2021.1871823 |