دورية أكاديمية
Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon
| العنوان: | Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon |
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| المؤلفون: | Peter Thelma Ngwa Niba, Akindeh Mbuh Nji, Jean Paul Kengne Chedjou, Helle Hansson, Emma Filtenborg Hocke, Innocent Mbulli Ali, Olivia Achonduh-Atijegbe, Marie-Solange B. Evehe, Marie Helene Munck Jørgensen, Calvino Tah Fomboh, Liwang Cui, Gillian Stresman, Jude D. Bigoga, Michael Alifrangis, Wilfred F. Mbacham |
| المصدر: | International Journal of Infectious Diseases, Vol 132, Iss , Pp 108-117 (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Plasmodium falciparum, Drug resistance, Evolution, Artemisinin-based combination therapies, Targeted amplicon deep sequencing, Cameroon, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Objectives: This study aimed to investigate the evolution of Plasmodium falciparum antimalarial drug resistance markers by comparing the pre- and post-adoption of artemisinin-based combination therapies (ACTs) in Yaounde, Cameroon. Methods: The molecular characterization of known antimalarial drug resistance markers (Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, and Pfk13) in P. falciparum-positive samples collected in 2014 and 2019-2020 was achieved using nested polymerase chain reaction, followed by targeted amplicon deep sequencing on the Illumina MiSeq platform. Data derived were compared with those published during the pre-ACT adoption period from 2004 to 2006. Results: A high prevalence of Pfmdr1 184F, Pfdhfr 51I/59R/108N, and Pfdhps 437G mutant alleles was observed during the post-ACT adoption period. The Pfcrt 76T and Pfmdr1 86Y mutant alleles significantly declined between 2004 and 2020 (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1201-9712 18849881 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1201971223001297; https://doaj.org/toc/1201-9712 |
| DOI: | 10.1016/j.ijid.2023.03.050 |
| URL الوصول: | https://doaj.org/article/84a188498819420389f5443c28e4bbc4 |
| رقم الأكسشن: | edsdoj.84a188498819420389f5443c28e4bbc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 12019712 18849881 |
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| DOI: | 10.1016/j.ijid.2023.03.050 |