دورية أكاديمية

The Host Immune Response to Scedosporium/Lomentospora

التفاصيل البيبلوغرافية
العنوان: The Host Immune Response to Scedosporium/Lomentospora
المؤلفون: Idoia Buldain, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Aitor Rementeria, Fernando L. Hernando, Andoni Ramirez-Garcia
المصدر: Journal of Fungi, Vol 7, Iss 2, p 75 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Scedosporium, Lomentospora, immune response, cytokine, macrophage, lymphocyte, Biology (General), QH301-705.5
الوصف: Infections caused by the opportunistic pathogens Scedosporium/Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium/Lomentospora cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against L. prolificans. Moreover, a great number of Scedosporium/Lomentospora antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to Scedosporium/Lomentospora.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2309-608X
Relation: https://www.mdpi.com/2309-608X/7/2/75; https://doaj.org/toc/2309-608X
DOI: 10.3390/jof7020075
URL الوصول: https://doaj.org/article/84d7d57410d64eeeaa6405bda06a6e7b
رقم الأكسشن: edsdoj.84d7d57410d64eeeaa6405bda06a6e7b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2309608X
DOI:10.3390/jof7020075