دورية أكاديمية
Widespread human exposure to ledanteviruses in Uganda: A population study.
| العنوان: | Widespread human exposure to ledanteviruses in Uganda: A population study. |
|---|---|
| المؤلفون: | James G Shepherd, Shirin Ashraf, Jesus F Salazar-Gonzalez, Maria G Salazar, Robert G Downing, Henry Bukenya, Hanna Jerome, Joseph T Mpanga, Chris Davis, Lily Tong, Vattipally B Sreenu, Linda A Atiku, Nicola Logan, Ezekiel Kajik, Yafesi Mukobi, Cyrus Mungujakisa, Michael V Olowo, Emmanuel Tibo, Fred Wunna, Hollie Jackson Ireland, Andrew E Blunsum, Iyanuoluwani Owolabi, Ana da Silva Filipe, Josephine Bwogi, Brian J Willett, Julius J Lutwama, Daniel G Streicker, Pontiano Kaleebu, Emma C Thomson |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 18, Iss 7, p e0012297 (2024) |
| بيانات النشر: | Public Library of Science (PLoS), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
| الوصف: | Le Dantec virus (LDV), assigned to the species Ledantevirus ledantec, genus Ledantevirus, family Rhabdoviridae has been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human case of undifferentiated fever in Uganda by metagenomic sequencing and demonstrate a serological response using ELISA and pseudotype neutralisation. By screening 997 individuals sampled in 2016, we show frequent exposure to ledanteviruses with 76% of individuals seropositive in Western Uganda, but lower seroprevalence in other areas. Serological cross-reactivity as measured by pseudotype-based neutralisation was confined to ledanteviruses, indicating population seropositivity may represent either exposure to LDV or related ledanteviruses. We also describe the discovery of a closely related ledantevirus in blood from the synanthropic rodent Mastomys erythroleucus. Ledantevirus infection is common in Uganda but is geographically heterogenous. Further surveys of patients presenting with acute fever are required to determine the contribution of these emerging viruses to febrile illness in Uganda. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1935-2727 1935-2735 |
| Relation: | https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735 |
| DOI: | 10.1371/journal.pntd.0012297 |
| URL الوصول: | https://doaj.org/article/85464e48cbbd4c34a14d890e9ac28189 |
| رقم الأكسشن: | edsdoj.85464e48cbbd4c34a14d890e9ac28189 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19352727 19352735 |
|---|---|
| DOI: | 10.1371/journal.pntd.0012297 |