دورية أكاديمية
Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma
| العنوان: | Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma |
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| المؤلفون: | Weiyu Kong, Jiaxin He, Qinyao Zhou, Xin Zhou, Xiyi Wei, Yonglin Yang, Yiwen Mei, Shuai Wang, Xi Zhang, Bing Yao, Yulin Yue, Jiali Xu, Minjun Jiang, Chen Xu |
| المصدر: | Heliyon, Vol 10, Iss 13, Pp e33554- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Histone lactylation, Cancer-associated fibroblasts, Tumour microenvironment, TIMP1, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Recent research emphasised the indispensable role of histone lactylation in the activation of hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell carcinoma, which normally causes a metabolic shift in cancer cells and increases lactate production, eventually creating a lactate-enriched tumour microenvironment. Cancer-associated fibroblasts (CAFs) promote tumour progression, which is also vital in clear cell renal cell carcinoma. Therefore, this study investigated histone lactylation in CAFs and its impact on patient survival. Multiomics technology was employed to determine the role of histone lactylation-related genes in the evolution of CAFs which correlated with the function and molecular signatures of CAFs. The results suggested that TIMP1 was the hub gene of histone lactylation-related genes in clear cell renal cell carcinoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024095859; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e33554 |
| URL الوصول: | https://doaj.org/article/c85578acb1f84089a574575a6555736d |
| رقم الأكسشن: | edsdoj.85578acb1f84089a574575a6555736d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e33554 |