دورية أكاديمية
Detail Synthetic Study of Infrared Fluorescent Dyes: Design, Synthesis and Chemical Properties of their Photodynamic Therapy Probes
| العنوان: | Detail Synthetic Study of Infrared Fluorescent Dyes: Design, Synthesis and Chemical Properties of their Photodynamic Therapy Probes |
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| المؤلفون: | Lavanya Gopala, Yi-Jia Yan, Zhi-Long Chen |
| المصدر: | Chemical Review and Letters, Vol 5, Iss 1, Pp 12-67 (2022) |
| بيانات النشر: | Iranian Chemical Science and Technologies Association, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | bodipy, photodynamic therapy, biological probes, photosensitizers, fluorescence, qsar-studies, Chemistry, QD1-999 |
| الوصف: | Dipyrromethene boron difluoride (BODIPY) derivatives can be used as effective photosensitizers (PS’s) to eradicate a broad spectrum of microbes that threaten the global population health. Moreover, these compounds could be used in diagnostic or therapy, controlling the balance between the fluorescence emission and the photodynamic activity. There is still much work to be done in the search for ideal PS’s with applications in photodynamic therapy (PDT). To effectively use near infrared region BODIPY dyes for labelling during biological analyses, or as biomarkers in biomedical applications such as imaging diagnosis, a hydrophilic character is usually required. It was found that the introduction of the strong electron-withdrawing group at the meso position in the BODIPY skeleton was responsible for the drastic bathochromic shift in the absorption spectrum. Several studies on the development of small molecule fluorescent probes have been performed with short wavelengths and with poor water solubility. There should be new investigations to obtain more information on the mechanisms of photodynamic action relating to cell damage and experiments in vivo infection models. In order to understand the effect of the substituents, a predictive quantitative structure-activity relationship (QSAR) regression model, based on theoretical holistic molecular descriptors as developed. An even better fluorescent probe would combine the photostability of the BODIPY group with a chromophore that absorbs at longer wavelength that makes for better light penetration in cells and tissues. In this review, we will summarize ideas on different wavelengths and hydroelectric abilities through modifications of molecular structures of the biological probe molecule. BODIPY’s materials and chemical modification methods for modulating the optical properties presented here could be versatile for developing efficient photo-responsive bio-related materials to control the biological activities and efficient quenchers on the biotechnological assays with labelled biomolecules. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2676-7279 2645-4947 |
| Relation: | https://www.chemrevlett.com/article_132114_2a1357df57949f5b17768ed6da48a2ba.pdf; https://doaj.org/toc/2676-7279; https://doaj.org/toc/2645-4947 |
| DOI: | 10.22034/crl.2021.287098.1109 |
| URL الوصول: | https://doaj.org/article/d858fc24fb524e7583b6cbbed84e8760 |
| رقم الأكسشن: | edsdoj.858fc24fb524e7583b6cbbed84e8760 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26767279 26454947 |
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| DOI: | 10.22034/crl.2021.287098.1109 |