دورية أكاديمية
Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones
| العنوان: | Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones |
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| المؤلفون: | T. I. Chaban, Yu. E. Matiychuk, Volodymyr V. Ogurtsov, Igor G. Chaban, Vasyl S. Matiychuk |
| المصدر: | Журнал органічної та фармацевтичної хімії, Vol 17, Iss 3, Pp 15-20 (2019) |
| بيانات النشر: | National University of Pharmacy (Kharkiv), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | organic synthesis, thiazolopyridines, antioxidant activity, Chemistry, QD1-999 |
| الوصف: | Aim. To expand the synthetic potential of thiazolo[4,5-b]pyridines, study the reactivity and perform the pharmacological screening of the antioxidant activity of the novel compounds synthesized. Results and discussion. A series of novel 3-aryl-5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridine-2-ones were obtained as a result of the interaction of 3-aryl-4-iminothiazolidine-2-ones with ethyl acetoacetate. At this stage the resulting 3-phenyl-5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was modified in position 5 in the acylation reaction. For all compounds synthesized the primary pharmacological screening of the antioxidant activity was performed; the results showed the potential for the search of antioxidant agents among thiazolo[4,5-b]pyridine-2-ones. Experimental part. By the reactions of [3+3]-cyclocondensation and acylation 12 novel thiazolo[4,5-b]pyridine-2-ones were obtained. The structure of all compounds synthesized was confirmed by the method of 1H NMR-spectroscopy and the data of elemental analysis. The antioxidant activity of the compounds synthesized was investigated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radical. Conclusions. 12 novel thiazolo[4,5-b]pyridines have been synthesized, their antioxidant properties have been investigated, and prospectivity for the search of novel antioxidant agents among thiazolo[4,5-b]pyridines has been shown. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2308-8303 2518-1548 |
| Relation: | http://ophcj.nuph.edu.ua/article/view/ophcj.19.174239/177690; https://doaj.org/toc/2308-8303; https://doaj.org/toc/2518-1548 |
| DOI: | 10.24959/ophcj.19.174239 |
| URL الوصول: | https://doaj.org/article/85dbb918874d422db507499df66b52e4 |
| رقم الأكسشن: | edsdoj.85dbb918874d422db507499df66b52e4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23088303 25181548 |
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| DOI: | 10.24959/ophcj.19.174239 |