دورية أكاديمية
Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
| العنوان: | Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients |
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| المؤلفون: | Hinz Jose, Gehoff Philipp, Schotola Hanna, Hosseini Morteza, Didilis Vassilios N, Jebran Ahmad, Gehoff Anastasia, Wiese Christoph H, Schulz Egbert, Schoendube Friedrich, Popov Aron |
| المصدر: | Journal of Cardiothoracic Surgery, Vol 7, Iss 1, p 39 (2012) |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Surgery LCC:Anesthesiology |
| مصطلحات موضوعية: | Cardiac surgery, Statin therapy, Hemodynamic, Outcome, Surgery, RD1-811, Anesthesiology, RD78.3-87.3 |
| الوصف: | Abstract Background Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome. Methods In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher’s-Exact-Test, and Student’s-T-test. A p value Results There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI) . The no-statin group had a significantly higher SVRI (882 ± 206 vs. 1050 ± 501 dyn s/cm5/m2, p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins. Conclusions Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1749-8090 |
| Relation: | http://www.cardiothoracicsurgery.org/content/7/1/39; https://doaj.org/toc/1749-8090 |
| DOI: | 10.1186/1749-8090-7-39 |
| URL الوصول: | https://doaj.org/article/85e257bfeedc4c8fac1c607091017fa2 |
| رقم الأكسشن: | edsdoj.85e257bfeedc4c8fac1c607091017fa2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17498090 |
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| DOI: | 10.1186/1749-8090-7-39 |