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Analysis of HRAS mutations in Japanese patients with oral squamous cell carcinoma

التفاصيل البيبلوغرافية
العنوان: Analysis of HRAS mutations in Japanese patients with oral squamous cell carcinoma
المؤلفون: Masahiro Uchibori, Yuko Osawa, Yuuki Ishii, Takayuki Aoki, Yoshihide Ota, Minoru Kimura
المصدر: Advances in Oral and Maxillofacial Surgery, Vol 1, Iss , Pp 100021- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Internal medicine
LCC:Surgery
مصطلحات موضوعية: HRAS, Oral squamous cell carcinoma, Japanese, Chewing tobacco, Internal medicine, RC31-1245, Surgery, RD1-811
الوصف: Objectives: The incidence of oral squamous cell carcinoma (OSCC) is associated with chewing tobacco and heavy consumption of alcohol. OSCC is also associated with Harvey rat sarcoma viral proto-oncogene homolog (HRAS) gene mutations, which are known to be high-risk factors for poor survival outcomes in patients with OSCC. In this study, we analysed HRAS mutations in Japanese patients with OSCC. Methods: Tumours and oral mucosal tissue samples were collected from 84 treatment-naïve patients with OSCC, between April 2010 and November 2012 in the Department of Oral and Maxillofacial Surgery at a university hospital in Japan. Results: An HRAS mutation was identified in one of the 84 tumours (1.2%) using standard Sanger sequencing. This mutation occurred in codon 13 (c.38G > T) of exon 2, and it corresponded to amino acid substitution p.Gly13Val. Statistical analysis demonstrated that HRAS mutations were associated with chewing tobacco (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2667-1476
Relation: http://www.sciencedirect.com/science/article/pii/S266714762100008X; https://doaj.org/toc/2667-1476
DOI: 10.1016/j.adoms.2021.100021
URL الوصول: https://doaj.org/article/e85e76afc45d4e5494955a97066b9bbb
رقم الأكسشن: edsdoj.85e76afc45d4e5494955a97066b9bbb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26671476
DOI:10.1016/j.adoms.2021.100021