دورية أكاديمية
Cancer stem cells: therapeutic implications and perspectives in cancer therapy
| العنوان: | Cancer stem cells: therapeutic implications and perspectives in cancer therapy |
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| المؤلفون: | Lu Han, Sanjun Shi, Tao Gong, Zhirong Zhang, Xun Sun |
| المصدر: | Acta Pharmaceutica Sinica B, Vol 3, Iss 2, Pp 65-75 (2013) |
| بيانات النشر: | Elsevier, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Cancer stem cells, Cancer therapy, CSC marker, CSC-targeted mechanism, Resistance, Hedgehog, Notch, Wnt, CSC niche, Quiescent state, miRNA expression, Apoptosis, Differentiation, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-3835 2211-3843 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2211383513000208; https://doaj.org/toc/2211-3835; https://doaj.org/toc/2211-3843 |
| DOI: | 10.1016/j.apsb.2013.02.006 |
| URL الوصول: | https://doaj.org/article/860f43cfde7e4db18e7b7187dd585dbb |
| رقم الأكسشن: | edsdoj.860f43cfde7e4db18e7b7187dd585dbb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22113835 22113843 |
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| DOI: | 10.1016/j.apsb.2013.02.006 |