دورية أكاديمية
Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis?
| العنوان: | Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis? |
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| المؤلفون: | Rikang Wang, Shuai Zhang, Rahul Previn, Di Chen, Yi Jin, Guangqian Zhou |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 12, p 3794 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | chondrocyte dysfunction, osteoarthritis, FoxO, oxidative stress, autophagy, aging, articular cartilage, molecular target, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Chondrocyte dysfunction occurs during the development of osteoarthritis (OA), typically resulting from a deleterious increase in oxidative stress. Accordingly, strategies for arresting oxidative stress-induced chondrocyte dysfunction may lead to new potential therapeutic targets for OA treatment. Forkhead box O (FoxO) transcription factors have recently been shown to play a protective role in chondrocyte dysfunction through the regulation of inflammation, autophagy, aging, and oxidative stress. They also regulate growth, maturation, and matrix synthesis in chondrocytes. In this review, we discuss the recent progress made in the field of oxidative stress-induced chondrocyte dysfunction. We also discuss the protective role of FoxO transcription factors as potential molecular targets for the treatment of OA. Understanding the function of FoxO transcription factors in the OA pathology may provide new insights that will facilitate the development of next-generation therapies to prevent OA development and to slow OA progression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/19/12/3794; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms19123794 |
| URL الوصول: | https://doaj.org/article/8639a47ccd224ffe977f9ae31ea825d5 |
| رقم الأكسشن: | edsdoj.8639a47ccd224ffe977f9ae31ea825d5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms19123794 |