دورية أكاديمية
Epigenetic therapies for neuroblastoma: immunogenicity awakens
| العنوان: | Epigenetic therapies for neuroblastoma: immunogenicity awakens |
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| المؤلفون: | Carlos Jiménez, Lucas Moreno, Miguel F. Segura |
| المصدر: | Molecular Oncology, Vol 17, Iss 5, Pp 718-721 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | histone deacetylase inhibitors, immunotherapy, major histocompatibility complex class I, neuroblastoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | The development of immunotherapies for neuroblastoma remains challenging owing to the low immunogenicity of neuroblastoma cells, as reflected by the low expression of one of the main triggers of immune recognition, the major histocompatibility complex class I (MHC‐I). Cornel et al. showed that epigenetic modulation of neuroblastoma cells with a histone deacetylase inhibitor can boost the expression of major histocompatibility complex class I, among other immune receptors, priming their recognition by T‐ and natural killer cells. By leveraging the developmentally related aberrant epigenetic landscapes of neuroblastoma, these discoveries pave the way to overcome a major limitation in the field of neuroblastoma immunotherapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1878-0261 1574-7891 |
| Relation: | https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261 |
| DOI: | 10.1002/1878-0261.13404 |
| URL الوصول: | https://doaj.org/article/866e3a0fadcf45a2afe16749205dd5a5 |
| رقم الأكسشن: | edsdoj.866e3a0fadcf45a2afe16749205dd5a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18780261 15747891 |
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| DOI: | 10.1002/1878-0261.13404 |