دورية أكاديمية
ABC Transporters in Bacterial Nanomachineries
العنوان: | ABC Transporters in Bacterial Nanomachineries |
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المؤلفون: | Florestan L. Bilsing, Manuel T. Anlauf, Eymen Hachani, Sakshi Khosa, Lutz Schmitt |
المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 7, p 6227 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | ABC transporter, nanomachineries, Mac system, Lpt system, Mla system, Lol system, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Members of the superfamily of ABC transporters are found in all domains of life. Most of these primary active transporters act as isolated entities and export or import their substrates in an ATP-dependent manner across biological membranes. However, some ABC transporters are also part of larger protein complexes, so-called nanomachineries that catalyze the vectorial transport of their substrates. Here, we will focus on four bacterial examples of such nanomachineries: the Mac system providing drug resistance, the Lpt system catalyzing vectorial LPS transport, the Mla system responsible for phospholipid transport, and the Lol system, which is required for lipoprotein transport to the outer membrane of Gram-negative bacteria. For all four systems, we tried to summarize the existing data and provide a structure-function analysis highlighting the mechanistical aspect of the coupling of ATP hydrolysis to substrate translocation. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/24/7/6227; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms24076227 |
URL الوصول: | https://doaj.org/article/867591361c994a67ae73b0b133b7393a |
رقم الأكسشن: | edsdoj.867591361c994a67ae73b0b133b7393a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms24076227 |