دورية أكاديمية
Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US.
العنوان: | Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US. |
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المؤلفون: | Lorie Benning, Elizabeth T Golub, Kathryn Anastos, Audrey L French, Mardge Cohen, Douglas Gilbert, Patrick Gillevet, Elisaphane Munyazesa, Alan L Landay, Masoumeh Sikaroodi, Gregory T Spear |
المصدر: | PLoS ONE, Vol 9, Iss 5, p e96844 (2014) |
بيانات النشر: | Public Library of Science (PLoS), 2014. |
سنة النشر: | 2014 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Previous studies have shown that alterations of the bacterial microbiota in the lower female genital tract influence susceptibility to HIV infection and shedding. We assessed geographic differences in types of genital microbiota between HIV-infected and uninfected women from Rwanda and the United States.Genera of lower genital tract bacterial microbiota were identified by high-throughput pyrosequencing of the 16S rRNA gene from 46 US women (36 HIV-infected, 10 HIV-uninfected) and 40 Rwandan women (18 HIV-infected, 22 HIV-uninfected) with similar proportions of low (0-3) Nugent scores. Species of Lactobacillus were identified by assembling sequences along with reference sequences into phylogenetic trees. Prevalence of genera and Lactobacillus species were compared using Fisher's exact tests.Overall the seven most prevalent genera were Lactobacillus (74%), Prevotella (56%), Gardnerella (55%), Atopobium (42%), Sneathia (37%), Megasphaera (30%), and Parvimonas (26%), observed at similar prevalences comparing Rwandan to US women, except for Megasphaera (20% vs. 39%, p = 0.06). Additionally, Rwandan women had higher frequencies of Mycoplasma (23% vs. 7%, p = 0.06) and Eggerthella (13% vs. 0%, p = 0.02), and lower frequencies of Lachnobacterium (8% vs. 35%, p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC4016010?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0096844 |
URL الوصول: | https://doaj.org/article/86aebfbfd7744f01afec8f9b1a924c7c |
رقم الأكسشن: | edsdoj.86aebfbfd7744f01afec8f9b1a924c7c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
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DOI: | 10.1371/journal.pone.0096844 |