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Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US.

التفاصيل البيبلوغرافية
العنوان: Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US.
المؤلفون: Lorie Benning, Elizabeth T Golub, Kathryn Anastos, Audrey L French, Mardge Cohen, Douglas Gilbert, Patrick Gillevet, Elisaphane Munyazesa, Alan L Landay, Masoumeh Sikaroodi, Gregory T Spear
المصدر: PLoS ONE, Vol 9, Iss 5, p e96844 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Previous studies have shown that alterations of the bacterial microbiota in the lower female genital tract influence susceptibility to HIV infection and shedding. We assessed geographic differences in types of genital microbiota between HIV-infected and uninfected women from Rwanda and the United States.Genera of lower genital tract bacterial microbiota were identified by high-throughput pyrosequencing of the 16S rRNA gene from 46 US women (36 HIV-infected, 10 HIV-uninfected) and 40 Rwandan women (18 HIV-infected, 22 HIV-uninfected) with similar proportions of low (0-3) Nugent scores. Species of Lactobacillus were identified by assembling sequences along with reference sequences into phylogenetic trees. Prevalence of genera and Lactobacillus species were compared using Fisher's exact tests.Overall the seven most prevalent genera were Lactobacillus (74%), Prevotella (56%), Gardnerella (55%), Atopobium (42%), Sneathia (37%), Megasphaera (30%), and Parvimonas (26%), observed at similar prevalences comparing Rwandan to US women, except for Megasphaera (20% vs. 39%, p = 0.06). Additionally, Rwandan women had higher frequencies of Mycoplasma (23% vs. 7%, p = 0.06) and Eggerthella (13% vs. 0%, p = 0.02), and lower frequencies of Lachnobacterium (8% vs. 35%, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4016010?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0096844
URL الوصول: https://doaj.org/article/86aebfbfd7744f01afec8f9b1a924c7c
رقم الأكسشن: edsdoj.86aebfbfd7744f01afec8f9b1a924c7c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0096844