دورية أكاديمية
Modeling Superparamagnetic Particles in Blood Flow for Applications in Magnetic Drug Targeting
| العنوان: | Modeling Superparamagnetic Particles in Blood Flow for Applications in Magnetic Drug Targeting |
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| المؤلفون: | Iris Rukshin, Josef Mohrenweiser, Pengtao Yue, Shahriar Afkhami |
| المصدر: | Fluids, Vol 2, Iss 2, p 29 (2017) |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Thermodynamics LCC:Descriptive and experimental mechanics |
| مصطلحات موضوعية: | magnetic drug targeting, superparamagnetic nanoparticles, blood flow, Thermodynamics, QC310.15-319, Descriptive and experimental mechanics, QC120-168.85 |
| الوصف: | Magnetic drug targeting is a technique that involves the binding of medicine to magnetizable particles to allow for more specific transport to the target location. This has recently come to light as a method of drug delivery that reduces the disadvantages of conventional, systemic treatments. This study developed a mathematical model for tracking individual superparamagnetic nanoparticles in blood flow in the presence of an externally applied magnetic field. The model considers the magnetic attraction between the particles and the external magnet, influence of power law flow, diffusive interaction between the particles and blood, and random collisions with red blood cells. A stochastic system of differential equations is presented and solved numerically to simulate the paths taken by particles in a blood vessel. This study specifically focused on localized cancer treatment, in which a surface tumor is accessed through smaller blood vessels, which are more conducive to this delivery method due to slower flow velocities and smaller diameters. The probability of the particles reaching the tumor location is found to be directly dependent on ambient factors; thus, diffusion through Brownian motion and red blood cell collisions, different magnetic field and force models, blood viscosities, and release points are considered. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2311-5521 |
| Relation: | http://www.mdpi.com/2311-5521/2/2/29; https://doaj.org/toc/2311-5521 |
| DOI: | 10.3390/fluids2020029 |
| URL الوصول: | https://doaj.org/article/d86b89a2d6634a558c4b6f292e0f1d94 |
| رقم الأكسشن: | edsdoj.86b89a2d6634a558c4b6f292e0f1d94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23115521 |
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| DOI: | 10.3390/fluids2020029 |