دورية أكاديمية
Mesalamine-Induced Myocarditis and Coronary Vasculitis in a Pediatric Ulcerative Colitis Patient: A Case Report
| العنوان: | Mesalamine-Induced Myocarditis and Coronary Vasculitis in a Pediatric Ulcerative Colitis Patient: A Case Report |
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| المؤلفون: | Elimarys Perez-Colon, Gul H. Dadlani, Ivan Wilmot, Michelle Miller |
| المصدر: | Case Reports in Pediatrics, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | Pediatrics, RJ1-570 |
| الوصف: | Mesalamine-containing products are often a first-line treatment for ulcerative colitis. Severe adverse reactions to these products, including cardiovascular toxicity, are rarely seen in pediatric patients. We present a case of a 16-year-old boy with ulcerative colitis treated with Asacol, a mesalamine-containing product, who developed sudden onset chest pain after four weeks on therapy. Serial electrocardiograms showed nonspecific ST segment changes, an echocardiogram showed mildly decreased left ventricular systolic function with mild to moderate left ventricular dilation and coronary ectasia, and his troponins were elevated. Following Asacol discontinuation, his chest pain resolved, troponins were trending towards normal, left ventricular systolic function normalized, and coronary ectasia improved within 24 hours suggesting an Asacol-associated severe drug reaction. Mesalamine-induced cardiovascular toxicity, although rare, may represent a life-threatening disorder. Therefore, every patient presenting with acute chest pain should receive a workup to rule out this rare drug-induced disorder. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-6803 2090-6811 |
| Relation: | https://doaj.org/toc/2090-6803; https://doaj.org/toc/2090-6811 |
| DOI: | 10.1155/2011/524364 |
| URL الوصول: | https://doaj.org/article/86be151eb8804d42ab6194595e06d1d3 |
| رقم الأكسشن: | edsdoj.86be151eb8804d42ab6194595e06d1d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20906803 20906811 |
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| DOI: | 10.1155/2011/524364 |