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Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury

التفاصيل البيبلوغرافية
العنوان: Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury
المؤلفون: Jing Zhang, Xin Guo, Taiji Hamada, Seiya Yokoyama, Yuka Nakamura, Jianbo Zheng, Nozomu Kurose, Yasuhito Ishigaki, Hidetaka Uramoto, Akihide Tanimoto, Sohsuke Yamada
المصدر: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2509 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: PRDX4, liver injury, oxidative stress, cholestasis, BDL, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) in both the intracellular compartments and extracellular space. In this study, we examined the in vivo net effects of PRDX4 overexpression in a murine model of cholestasis. To induce cholestatic liver injury, we subjected C57BL/6J wild-type (WT) or human PRDX4 (hPRDX4) transgenic (Tg) mice to sham or bile duct ligation (BDL) surgery for seven days. Our results showed that the liver necrosis area was significantly suppressed in Tg BDL mice with a reduction in the severity of liver injuries. Furthermore, PRDX4 overexpression markedly reduced local and systemic oxidative stress generated by BDL. In addition, suppression of inflammatory cell infiltration, reduced proliferation of hepatocytes and intrahepatic bile ducts, and less fibrosis were also found in the liver of Tg BDL mice, along with a reduced mortality rate after BDL surgery. Interestingly, the composition of the hepatic bile acids (BAs) was more beneficial for Tg BDL mice than for WT BDL mice, suggesting that PRDX4 overexpression may affect BA metabolism during cholestasis. These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: http://www.mdpi.com/1422-0067/19/9/2509; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms19092509
URL الوصول: https://doaj.org/article/86dc3865e80143fabb0b98a6c8dc130f
رقم الأكسشن: edsdoj.86dc3865e80143fabb0b98a6c8dc130f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms19092509