دورية أكاديمية
Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues
| العنوان: | Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues |
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| المؤلفون: | Salwa Sabet, Shrouk Khalaf El-Sayed, Hossam Taha Mohamed, Mohamed El-Shinawi, Mona M Mohamed |
| المصدر: | Tumor Biology, Vol 39 (2017) |
| بيانات النشر: | IOS Press, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, −1082A/G, −819T/C and −592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non–inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. We enrolled 105 breast cancer tissue (72 non–inflammatory breast cancer and 33 inflammatory breast cancer) patients and we determined the three studied single nucleotide polymorphisms in all samples by polymerase chain reaction restriction fragment length polymorphism and investigated their association with the disease and with various prognostic factors. In addition, we assessed the expression of interleukin-10 gene by real-time quantitative reverse transcription polymerase chain reaction and the correlation between studied single nucleotide polymorphisms and interleukin-10 messenger RNA expression. We found co-dominant effect as the best inheritance model (in the three studied single nucleotide polymorphisms in non–inflammatory breast cancer and inflammatory breast cancer samples), and we didn’t identify any association between single nucleotide polymorphisms genotypes and breast cancer prognostic factors. However, GCC haplotype was found highly associated with inflammatory breast cancer risk (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1423-0380 10104283 |
| Relation: | https://doaj.org/toc/1423-0380 |
| DOI: | 10.1177/1010428317713393 |
| URL الوصول: | https://doaj.org/article/86ea8ed98e3d41669feba2a78d07fd77 |
| رقم الأكسشن: | edsdoj.86ea8ed98e3d41669feba2a78d07fd77 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14230380 10104283 |
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| DOI: | 10.1177/1010428317713393 |