دورية أكاديمية

PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer

التفاصيل البيبلوغرافية
العنوان: PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer
المؤلفون: Lu Peng, Yujiao Zhao, Jiang Tan, Jingyao Hou, Xin Jin, Dong-Xu Liu, Baiqu Huang, Jun Lu
المصدر: Cell Death and Disease, Vol 15, Iss 7, Pp 1-11 (2024)
بيانات النشر: Nature Publishing Group, 2024.
سنة النشر: 2024
المجموعة: LCC:Cytology
مصطلحات موضوعية: Cytology, QH573-671
الوصف: Abstract Abnormal epigenetic modifications are involved in the regulation of Warburg effect in tumor cells. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have critical functions in cellular responses. PRMTs are deregulated in a variety of cancers, but their precise roles in Warburg effect in cancer is largely unknown. Experiments from the current study showed that PRMT1 was highly expressed under conditions of glucose sufficiency. PRMT1 induced an increase in the PKM2/PKM1 ratio through upregulation of PTBP1, in turn, promoting aerobic glycolysis in non-small cell lung cancer (NSCLC). The PRMT1 level in p53-deficient and p53-mutated NSCLC remained relatively unchanged while the expression was reduced in p53 wild-type NSCLC under conditions of glucose insufficiency. Notably, p53 activation under glucose-deficient conditions could suppress USP7 and further accelerate the polyubiquitin-dependent degradation of PRMT1. Melatonin, a hormone that inhibits glucose intake, markedly suppressed cell proliferation of p53 wild-type NSCLC, while a combination of melatonin and the USP7 inhibitor P5091 enhanced the anticancer activity in p53-deficient NSCLC. Our collective findings support a role of PRMT1 in the regulation of Warburg effect in NSCLC. Moreover, combination treatment with melatonin and the USP7 inhibitor showed good efficacy, providing a rationale for the development of PRMT1-based therapy to improve p53-deficient NSCLC outcomes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-4889
87260077
Relation: https://doaj.org/toc/2041-4889
DOI: 10.1038/s41419-024-06898-x
URL الوصول: https://doaj.org/article/87260077536749de8fef358bf0fecb45
رقم الأكسشن: edsdoj.87260077536749de8fef358bf0fecb45
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20414889
87260077
DOI:10.1038/s41419-024-06898-x