دورية أكاديمية
أعرض في EDS

Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association.

التفاصيل البيبلوغرافية
العنوان: Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association.
المؤلفون: Kirsten Anderson, Brenna Carey, Allison Martin, Christina Roark, Claudia Chalk, Marchele Nowell-Bostic, Brian Freed, Michael Aubrey, Bruce Trapnell, Andrew Fontenot
المصدر: PLoS ONE, Vol 14, Iss 3, p e0213179 (2019)
بيانات النشر: Public Library of Science (PLoS), 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of pulmonary surfactant in alveolar macrophages and alveoli, resulting in respiratory impairment and an increased risk of opportunistic infections. Autoimmune PAP is an autoimmune lung disease that is caused by autoantibodies directed against granulocyte-macrophage colony-stimulating factor (GM-CSF). A shared feature among many autoimmune diseases is a distinct genetic association to HLA alleles. In the present study, we HLA-typed patients with autoimmune PAP to determine if this disease had any HLA association. We analyzed amino acid and allele associations for HLA-A, B, C, DRB1, DQB1, DPB1, DRB3, DRB4 and DRB5 in 41 autoimmune PAP patients compared to 1000 ethnic-matched controls and did not find any HLA association with autoimmune PAP. Collectively, these data may suggest the absence of a genetic association to the HLA in the development of autoimmune PAP.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0213179
URL الوصول: https://doaj.org/article/87ed814ea9de47d2bf0509a8c337b269
رقم الأكسشن: edsdoj.87ed814ea9de47d2bf0509a8c337b269
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0213179