دورية أكاديمية
Downscaling of a Three-Dimensional Alveolar In Vitro Model for High-Throughput Screening of Inhalable Respiratory Sensitizers in the Food Industry
| العنوان: | Downscaling of a Three-Dimensional Alveolar In Vitro Model for High-Throughput Screening of Inhalable Respiratory Sensitizers in the Food Industry |
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| المؤلفون: | Sabina BURLA, Aline CHARY, Elisa MOSCHINI, Charlotte B. A. STOFFELS, Tommaso SERCHI, Carmen SOCACIU, Mihai A. SOCACIU, Arno C. GUTLEB |
| المصدر: | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology, Vol 80, Iss 1, Pp 7-23 (2023) |
| بيانات النشر: | AcademicPres, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Food processing and manufacture |
| مصطلحات موضوعية: | alveolar, air-liquid interface, cell surface markers, cytokines, in vitro, Food processing and manufacture, TP368-456 |
| الوصف: | Allergic diseases represent an increasing global health problem, among which food and respiratory allergies play an important part. Inhalation of sensitizers from food sources primes the immune system for an exacerbated response upon subsequent exposure via the ingestion route. With the increasing emergence of novel food additives and proteins and growing morbidity in both food and respiratory allergies, the hazard assessment of the allergenicity of food components is of paramount importance. A three-dimensional (3D) alveolar in vitro model for respiratory sensitization prediction was downscaled from the 6- to the 24-well plate insert format, to meet the industry’s high-throughput (HTS) screening requirements. The resemblance of the cellular architecture of the downscaled model to the alveolar region of the lung was evaluated through microscopy techniques and the functionality of the in vitro model was assessed following air-liquid interface (ALI) exposure to ammonium persulfate (APS). The model represents a promising in vitro tool to screen for the respiratory sensitization potential of food components in a fast and reliable approach. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2344-2344 2344-5300 |
| Relation: | https://journals.usamvcluj.ro/index.php/fst/article/view/14593; https://doaj.org/toc/2344-2344; https://doaj.org/toc/2344-5300 |
| DOI: | 10.15835/buasvmcn-fst:2023.0003 |
| URL الوصول: | https://doaj.org/article/880ce29f81d745abb3f1817de3eea359 |
| رقم الأكسشن: | edsdoj.880ce29f81d745abb3f1817de3eea359 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23442344 23445300 |
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| DOI: | 10.15835/buasvmcn-fst:2023.0003 |