دورية أكاديمية
Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)
| العنوان: | Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) |
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| المؤلفون: | Stefano Dore, Daniele Satta, Angelo Zinellu, Giacomo Boscia, Arturo Carta, Mario Fruschelli, Rita Serra, Antonio Pinna |
| المصدر: | Diseases, Vol 12, Iss 5, p 83 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | oculomotor tics, PANDAS, ASO antibodies, anti-DNase B antibodies, ESR, CRP, Medicine |
| الوصف: | Little is known about ocular tics in Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal infections (PANDAS). In this retrospective study, we examined the clinical records of children with motor tics referred to the Ophthalmology Unit, Azienda Ospedaliero-Universitaria di Sassari, Italy, in 2010–2019. The presence of ocular tics was investigated. Data about antistreptolysin O (ASO) and anti-DNase B antibody titers, erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP), and antibiotic use were recorded. Forty children (thirty-four boys and six girls; mean age: 7.65 ± 2.5 years) with motor tics were identified; thirty-three (82.5%) showed ocular tics. Children with ocular tics had significantly higher titers of anti-DNase B antibodies (p = 0.04) and CRP (p = 0.016) than those with extraocular tics. A diagnosis of PANDAS was made in 24 (60%) children. PANDAS children with oculomotor tics had significantly higher titers of anti-DNase B antibodies (p = 0.05) than those with extraocular tics. Oral antibiotics were given to 25/33 (76%) children with ocular tics and 21/24 (87.5%) with PANDAS. All treated patients showed marked improvement/complete resolution of symptoms. Results suggest that higher titers of anti-DNase B antibodies may be implicated in the pathogenesis of ocular tics in PANDAS. Oral antibiotics may be beneficial in improving ocular tics. Further research is necessary to confirm our findings. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12050083 2079-9721 |
| Relation: | https://www.mdpi.com/2079-9721/12/5/83; https://doaj.org/toc/2079-9721 |
| DOI: | 10.3390/diseases12050083 |
| URL الوصول: | https://doaj.org/article/a8820054cd4c479a9ac94fb08f84995f |
| رقم الأكسشن: | edsdoj.8820054cd4c479a9ac94fb08f84995f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12050083 20799721 |
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| DOI: | 10.3390/diseases12050083 |