دورية أكاديمية
The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized Placebo-Controlled Trial
| العنوان: | The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized Placebo-Controlled Trial |
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| المؤلفون: | Urszula Razny, Joanna Goralska, Philip C. Calder, Anna Gruca, Caroline E. Childs, Maria Kapusta, Krystyna Slowinska-Solnica, Aldona Dembinska-Kiec, Bogdan Solnica, Malgorzata Malczewska-Malec |
| المصدر: | Nutrients, Vol 13, Iss 9, p 3096 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | bone turnover, obesity, caloric restriction, n-3 PUFAs, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Weight loss contributes to an increased risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect of weight loss on bone health. The aim of this randomized, placebo-controlled, double-blind parallel trial was to investigate the effect of caloric restriction and n-3 PUFA supplement intake on osteogenic markers (carboxylated osteocalcin (Gla-OC); procollagen I N-terminal propeptide (PINP)), as well as a bone resorption marker (C-terminal telopeptide of type I collagen (CTX-I)) in a serum of 64 middle aged individuals (BMI 25–40 kg/m2) with abdominal obesity. Bone remodeling, metabolic and inflammatory parameters and adipokines were determined before and after 3 months of an isocaloric diet (2300–2400 kcal/day) or a low-calorie diet (1200 kcal/day for women and 1500 kcal/day for men) along with n-3 PUFA (1.8 g/day) or placebo capsules. CTX-I and adiponectin concentrations were increased following 7% weight loss independently of supplement use. Changes in CTX-I were positively associated with changes in adiponectin level (rho = 0.25, p = 0.043). Thus, an increase in serum adiponectin caused by body weight loss could adversely affect bone health. N-3 PUFAs were without effect. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13093096 2072-6643 |
| Relation: | https://www.mdpi.com/2072-6643/13/9/3096; https://doaj.org/toc/2072-6643 |
| DOI: | 10.3390/nu13093096 |
| URL الوصول: | https://doaj.org/article/ead8831db0be49b7920878a291497a3e |
| رقم الأكسشن: | edsdoj.8831db0be49b7920878a291497a3e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13093096 20726643 |
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| DOI: | 10.3390/nu13093096 |