دورية أكاديمية
Age-related aspects of cytokine profile of immune response in children with pertussis
| العنوان: | Age-related aspects of cytokine profile of immune response in children with pertussis |
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| المؤلفون: | O. P. Popova, M. S. Blyakher, I. M. Fedorova, S. I. Koteleva, I. V. Kapustin |
| المصدر: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 65, Iss 3, Pp 84-90 (2020) |
| بيانات النشر: | Ltd. “The National Academy of Pediatric Science and Innovation”, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | дети, коклюш, ифнγ, ил-2, ил-4, ил-6, ил-8, ил-10, Pediatrics, RJ1-570 |
| الوصف: | The article presents a comparative analysis of the cytokine network in 161 patients with pertussis under the age of 1 year and in 180 patients over the age of 1 year. The studies revealed lower production of immunoregulatory cytokines (interferon-γ and interleukin-2) in patients under the age of 1 year at all stages of the disease and with all variants of pertussis (both mono- and mixed infections). The researchers revealed the relationship between the level of interferon-γ production and the severity of pertussis. They revealed age differences in the interferon-8 production in patients with mixed infection, which can determine clinical features and cause bronchopulmonary complications. The authors demonstrated the features of the dynamics of spontaneous and induced production of interleukin-6 and anti-inflammatory cytokines (interleukin-4, interleukin-10) in children under the age of 1 year; these features can be considered as immunological markers determining the imperfection of the humoral response in patients with pertussis in this age group. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1027-4065 2500-2228 |
| Relation: | https://www.ped-perinatology.ru/jour/article/view/1154; https://doaj.org/toc/1027-4065; https://doaj.org/toc/2500-2228 |
| DOI: | 10.21508/1027-4065-2020-65-3-84-90 |
| URL الوصول: | https://doaj.org/article/e8846f7615c64ca080aa4b985458e09d |
| رقم الأكسشن: | edsdoj.8846f7615c64ca080aa4b985458e09d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10274065 25002228 |
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| DOI: | 10.21508/1027-4065-2020-65-3-84-90 |