دورية أكاديمية
City-level meteorological conditions modify the relationships between exposure to multiple air pollutants and the risk of pediatric hand, foot, and mouth disease in the Sichuan Basin, China
| العنوان: | City-level meteorological conditions modify the relationships between exposure to multiple air pollutants and the risk of pediatric hand, foot, and mouth disease in the Sichuan Basin, China |
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| المؤلفون: | Wennian Cai, Caiying Luo, Xiaoran Geng, Yuanyi Zha, Tao Zhang, Huadong Zhang, Changhong Yang, Fei Yin, Yue Ma, Tiejun Shui |
| المصدر: | Frontiers in Public Health, Vol 11 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Public aspects of medicine |
| مصطلحات موضوعية: | meteorological conditions, air pollution-HFMD associations, modification effects, air pollution, two-stage analysis, Public aspects of medicine, RA1-1270 |
| الوصف: | BackgroundSeveral studies have examined the effects of city-level meteorological conditions on the associations between meteorological factors and hand, foot, and mouth disease (HFMD) risk. However, evidence that city-level meteorological conditions modify air pollutant-HFMD associations is lacking.MethodsFor each of the 17 cities in the Sichuan Basin, we obtained estimates of the relationship between exposures to multiple air pollutants and childhood HFMD risk by using a unified distributed lag nonlinear model (DLNM). Multivariate meta-regression models were used to identify the effects of city-level meteorological conditions as effect modifiers. Finally, we conducted subgroup analyses of age and sex to explore whether the modification effects varied in different subgroups.ResultsThe associations between PM2.5/CO/O3 and HFMD risk showed moderate or substantial heterogeneity among cities (I2 statistics: 48.5%, 53.1%, and 61.1%). Temperature conditions significantly modified the PM2.5-HFMD association, while relative humidity and rainfall modified the O3-HFMD association. Low temperatures enhanced the protective effect of PM2.5 exposure against HFMD risk [PM2.5 100 μg/m3, at the 99th percentile: relative risk (RR) = 0.14, 95% CI: 0.03–0.60]. Low relative humidity increased the adverse effect of O3 exposure on HFMD risk (O3 >128.7 μg/m3, at the 99th percentile: RR = 2.58, 95% CI: 1.48–4.50). However, high rainfall decreased the risk of HFMD due to O3 exposure (O3: 14.1–41.4 μg/m3). In addition, the modification effects of temperature and relative humidity differed in the female and 3–5 years-old subgroups.ConclusionOur findings revealed moderate or substantial heterogeneity in multiple air pollutant-HFMD relationships. Temperature, relative humidity, and rainfall modified the relationships between PM2.5 or O3 exposure and HFMD risk. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2296-2565 29292255 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1140639/full; https://doaj.org/toc/2296-2565 |
| DOI: | 10.3389/fpubh.2023.1140639 |
| URL الوصول: | https://doaj.org/article/8847378ecf0b4f13a29292255f14ed02 |
| رقم الأكسشن: | edsdoj.8847378ecf0b4f13a29292255f14ed02 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22962565 29292255 |
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| DOI: | 10.3389/fpubh.2023.1140639 |