دورية أكاديمية
Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery.
العنوان: | Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery. |
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المؤلفون: | Shaul Yogev, Eyal D Schejter, Ben-Zion Shilo |
المصدر: | PLoS Biology, Vol 8, Iss 10 (2010) |
بيانات النشر: | Public Library of Science (PLoS), 2010. |
سنة النشر: | 2010 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini. Here we show that subcellular localization of Rhomboid proteases, which process Spi, determines the site of Spi release from neurons. Endoplasmic reticulum (ER) localization of Rhomboid 3 is essential for its ability to promote Spi secretion from axons, but not from cell bodies. We demonstrate that the ER extends throughout photoreceptor axons, and show that this feature facilitates the trafficking of the Spi precursor, the ligand chaperone Star, and Rhomboid 3 to axonal termini. Following this trafficking step, secretion from the axons is regulated in a manner similar to secretion from cell bodies. These findings uncover a role for the ER in trafficking proteins from the neuronal cell body to axon terminus. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1544-9173 1545-7885 |
Relation: | http://europepmc.org/articles/PMC2950126?pdf=render; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885 |
DOI: | 10.1371/journal.pbio.1000505 |
URL الوصول: | https://doaj.org/article/88654b2aa9764cda92801ff69b907f2b |
رقم الأكسشن: | edsdoj.88654b2aa9764cda92801ff69b907f2b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 15449173 15457885 |
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DOI: | 10.1371/journal.pbio.1000505 |