دورية أكاديمية
In silico and In vitro cytotoxic effect of prodigiosin-conjugated silver nanoparticles on liver cancer cells (HepG2)
| العنوان: | In silico and In vitro cytotoxic effect of prodigiosin-conjugated silver nanoparticles on liver cancer cells (HepG2) |
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| المؤلفون: | Ahmed I. El-Batal, Hoda H. El-Hendawy, Ahmed H. I. Faraag |
| المصدر: | BioTechnologia, Vol 98, Iss 3, Pp 225-243 (2018) |
| بيانات النشر: | Termedia Publishing House, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biotechnology |
| مصطلحات موضوعية: | silver nanoparticles, cytotoxic activity, Serratia marcescens, In silico, prodigiosin, Biotechnology, TP248.13-248.65 |
| الوصف: | This study demonstrates a novel approach for the synthesis of silver nanoparticles (AgNPs) against human liver cancer cell line (HepG2) using prodigiosin pigment isolated from Serratia marcescens. It further investigates the influence of various parameters such as initial pH, temperature, silver nitrate (AgNO 3 ) concentration, and prodigiosin concentration on stability and optical properties of synthesized prodigiosin AgNPs. Highly stable, spherical prodigiosin-conjugated AgNPs were synthesized with a mean diameter of 9.98 nm using a rapid one-step method. The cytotoxic activity investigated in the present study indicated that prodigiosin and prodigiosin-conjugated AgNPs possessed a strong cytotoxic potency against human liver cancer. The In silico molecular docking results of prodigiosin and prodigiosin-conjugated AgNPs are congruent with the In vitro studies and these AgNPs can be considered as good inhibitors of mitogen-activated protein kinase 1 (MEK kinases). The study opened the possibility of using prodigiosin-conjugated AgNPs to increase the efficiency of liver cancer treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0860-7796 2353-9461 |
| Relation: | https://www.termedia.pl/-In-silico-and-In-vitro-cytotoxic-effect-of-prodigiosin-conjugated-r-nsilver-nanoparticles-on-liver-cancer-cells-HepG2-,85,30833,1,1.html; https://doaj.org/toc/0860-7796; https://doaj.org/toc/2353-9461 |
| DOI: | 10.5114/bta.2017.70801 |
| URL الوصول: | https://doaj.org/article/a886834c7ba14765a4fc270a5d85d8db |
| رقم الأكسشن: | edsdoj.886834c7ba14765a4fc270a5d85d8db |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 08607796 23539461 |
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| DOI: | 10.5114/bta.2017.70801 |