دورية أكاديمية
Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase
| العنوان: | Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase |
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| المؤلفون: | Rinku Jain, Kyle V. Butler, Javier Coloma, Jian Jin, Aneel K. Aggarwal |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| بيانات النشر: | Nature Portfolio, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2′OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-017-01756-7 |
| URL الوصول: | https://doaj.org/article/8868ec6242b34c468df4cb1b113ec0bd |
| رقم الأكسشن: | edsdoj.8868ec6242b34c468df4cb1b113ec0bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-017-01756-7 |